One potential stressor that can affect preimplantation and postimplantation embryonic growth after in vitro fertilisation (IVF) is the pH of the human embryo culture medium, but no evidence exists to indicate which pH level is optimal for IVF.

Based on anecdotal evidence or mouse models, culture media manufacturers recommend a pH range of 7.2 to 7.4, and IVF laboratories routinely use a pH range of 7.25 to 7.3. Given the lack of randomised trials evaluating the effect of pH on live birth rate after IVF, this trial examines the effect of three different pH levels on the live birth rate.

This multicentre randomised trial will involve centres specialised in IVF in Egypt. Eligible couples for intracytoplasmic sperm injection (ICSI) will be randomised for embryo culture at pH 7.2, 7.3 or 7.4. The study is designed to detect 10 percentage points difference in live birth rate between the best and worst performing media with 93% power at a 1% significance level.

The primary outcome is the rate of live birth (delivery of one or more viable infants beyond the 20th week of gestation) after ICSI. Secondary clinical outcomes include biochemical pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, preterm births, birth weight, stillbirth, congenital malformation and cumulative live birth (within 1 year from randomisation).

Allele-In-One Human Blood Direct PCR Kit

ABP-PP-BD02100 100 RXNS Ask for price

Allele-In-One Human Blood Direct PCR Kit

ABP-PP-BD02500 500 RXNS Ask for price

Allele-In-One Mouse Tail Direct Lysis Buffer

ABP-PP-MT01100 100 RXNS Ask for price

Allele-In-One Mouse Tail Direct Lysis Buffer

ABP-PP-MT01500 500 RXNS Ask for price

Allele-In-One Mouse Tail Direct PCR Kit

ABP-PP-MT02100 100 RXNS Ask for price

Allele-In-One Mouse Tail Direct PCR Kit

ABP-PP-MT02500 500 RXNS Ask for price

Human nonmethylated oligonucleotide(NON)ELISA Kit

GA-E1908HM-48T 48T
EUR 289

Human nonmethylated oligonucleotide(NON)ELISA Kit

GA-E1908HM-96T 96T
EUR 466

Human nonmethylated oligonucleotide,NON ELISA Kit

201-12-1892 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Oligonucleotide Binding Fold Containing 1 Protein

20-abx262451
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Human nonmethylated oligonucleotide(NON)ELISA Kit

QY-E03624 96T
EUR 413

Human nonmethylated oligonucleotide,NON ELISA Kit

CN-04463H1 96T
EUR 452

Human nonmethylated oligonucleotide,NON ELISA Kit

CN-04463H2 48T
EUR 302

ELISA kit for Human Nonmethylated oligonucleotide (NON)

KTE62600-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Nonmethylated oligonucleotide (NON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Nonmethylated oligonucleotide (NON)

KTE62600-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Nonmethylated oligonucleotide (NON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Nonmethylated oligonucleotide (NON)

KTE62600-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Nonmethylated oligonucleotide (NON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Testis-specific kinase substrate (TSKS) polyclonal antibody

ABP-PAB-10265 100 ug Ask for price

Sentrin/SUMO-specific protease (SENP1) polyclonal antibody

ABP-PAB-11087 100 ug Ask for price

Ubiquitin specific protease 6 (USP6) polyclonal antibody

ABP-PAB-11313 100 ug Ask for price

Sentrin/SUMO-specific protease 1 (SENP1) polyclonal antibody

ABP-PAB-10330 100 ug Ask for price

Sentrin/SUMO-specific protease 1 (SENP1) polyclonal antibody

ABP-PAB-10331 100 ug Ask for price

SUMO1/sentrin specific protease 6 (SENP6) polyclonal antibody

ABP-PAB-10338 100 ug Ask for price

SUMO1/sentrin specific protease 6 (SENP6) polyclonal antibody

ABP-PAB-10339 100 ug Ask for price

Brain-specific angiogenesis inhibitor 1 (BAI1) polyclonal antibody

ABP-PAB-10421 100 ug Ask for price

Brain-specific angiogenesis inhibitor 2 (BAI2) polyclonal antibody

ABP-PAB-10422 100 ug Ask for price

Brain-specific angiogenesis inhibitor 3 (BAI3) polyclonal antibody

ABP-PAB-10423 100 ug Ask for price

Kallikrein 3 (KLK3, Prostate Specific Antigen, PSA) polyclonal antibody

ABP-PAB-10235 100 ug Ask for price

Sentrin/SUMO-specific protease 5 (SENP5, MGC27076) polyclonal antibody

ABP-PAB-10336 100 ug Ask for price

Sentrin/SUMO-specific protease 5 (SENP5, MGC27076) polyclonal antibody

ABP-PAB-10337 100 ug Ask for price

Sentrin/SUMO-specific protease 2, N-terminus (SENP2) polyclonal antibody

ABP-PAB-10332 100 ug Ask for price

Sentrin/SUMO-specific protease 2, C-terminus (SENP2) polyclonal antibody

ABP-PAB-10333 100 ug Ask for price

Sentrin/SUMO-specific protease 3, N-terminus (SENP3) polyclonal antibody

ABP-PAB-10334 100 ug Ask for price

Sentrin/SUMO-specific protease 3, C-terminus (SENP3) polyclonal antibody

ABP-PAB-10335 100 ug Ask for price

Sentrin/SUMO-specific protease 7, N-terminus (SENP7) polyclonal antibody

ABP-PAB-10340 100 ug Ask for price

Sentrin/SUMO-specific protease 7, C-terminus (SENP7) polyclonal antibody

ABP-PAB-10341 100 ug Ask for price

OBFC1 Oligonucleotide Binding Fold Containing 1 Human Recombinant Protein

PROTQ9H668 Regular: 10ug
EUR 317
Description: OBFC1 Human Recombinant produced in E. coli is. a single polypeptide chain containing 391 amino acids (1-368) and having a molecular mass of 44.5kDa. OBFC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Human Suppressor of G2 allele of SKP1 homolog, SUGT1 ELISA KIT

ELI-52628h 96 Tests
EUR 824

Bovine Suppressor of G2 allele of SKP1 homolog, SUGT1 ELISA KIT

ELI-13668b 96 Tests
EUR 928

Mouse Suppressor of G2 allele of SKP1 homolog, Sugt1 ELISA KIT

ELI-18768m 96 Tests
EUR 865

Mouse Ig gamma- 2A chain C region, A allele, Ighg ELISA KIT

ELI-47186m 96 Tests
EUR 865

REDD1 Specific (REDD1 specific) Antibody

abx237228-100ug 100 ug
EUR 509

TDRKH Specific (TDRKH specific) Antibody

abx238580-100ug 100 ug
EUR 509

Human TDRKH specific (TDRKH specific) ELISA Kit

abx259882-96tests 96 tests
EUR 911

Neuron Specific Peptide

5-01606 4 x 1mg Ask for price

ACADL-Specific Antibody

abx230064-100ug 100 ug
EUR 481

ADAM17-Specific Antibody

abx230139-100ug 100 ug
EUR 481

ADRA1A-Specific Antibody

abx230177-100ug 100 ug
EUR 481

ADRA2B-Specific Antibody

abx230179-100ug 100 ug
EUR 509

AFF1-Specific Antibody

abx230195-100ug 100 ug
EUR 481

AKAP11-Specific Antibody

abx230251-100ug 100 ug
EUR 481

AMPD1-Specific Antibody

abx230370-100ug 100 ug
EUR 509

ARF5-Specific Antibody

abx230534-100ug 100 ug
EUR 481

ARF6-Specific Antibody

abx230535-100ug 100 ug
EUR 481

ARHGEF9-Specific Antibody

abx230565-100ug 100 ug
EUR 481

ARSK-Specific Antibody

abx230613-100ug 100 ug
EUR 481

ATF2-Specific Antibody

abx230661-100ug 100 ug
EUR 481

ATP1A1-Specific Antibody

abx230692-100ug 100 ug
EUR 509

ATP1A2-Specific Antibody

abx230694-100ug 100 ug
EUR 509

ATP5G2-Specific Antibody

abx230708-100ug 100 ug
EUR 481

BAG1S-specific Antibody

abx230788-100ug 100 ug
EUR 509

BAI2-Specific Antibody

abx230791-100ug 100 ug
EUR 481

BAI3-Specific Antibody

abx230792-100ug 100 ug
EUR 481

Barkor-Specific Antibody

abx230806-100ug 100 ug
EUR 481

BRN2-Specific Antibody

abx230963-100ug 100 ug
EUR 481

BTF3L3-Specific Antibody

abx230976-100ug 100 ug
EUR 481

CAPG-Specific Antibody

abx231249-100ug 100 ug
EUR 481

Catalase-Specific Antibody

abx231302-100ug 100 ug
EUR 481

CCKAR-specific Antibody

abx231377-100ug 100 ug
EUR 481

CCKBR-specific Antibody

abx231378-100ug 100 ug
EUR 481

CCR2-specific Antibody

abx231390-100ug 100 ug
EUR 481

CCT6A-Specific Antibody

abx231401-100ug 100 ug
EUR 481

CD68-Specific Antibody

abx231493-100ug 100 ug
EUR 509

CDH10-specific Antibody

abx231546-100ug 100 ug
EUR 481

CDK1-Specific Antibody

abx231552-100ug 100 ug
EUR 481

CEACAM3-Specific Antibody

abx231578-100ug 100 ug
EUR 481

CEP350-Specific Antibody

abx231603-100ug 100 ug
EUR 481

CES7-Specific Antibody

abx231618-100ug 100 ug
EUR 481

CHST13-Specific Antibody

abx231693-100ug 100 ug
EUR 509

CISD2-Specific Antibody

abx231719-100ug 100 ug
EUR 481

CPNE9-Specific Antibody

abx231932-100ug 100 ug
EUR 481

CPT1B-specific Antibody

abx231944-100ug 100 ug
EUR 509

CPT1C-specific Antibody

abx231946-100ug 100 ug
EUR 481

CRLS1-Specific Antibody

abx231983-100ug 100 ug
EUR 509

CST2-Specific Antibody

abx232033-100ug 100 ug
EUR 481

MCL1L-specific Antibody

abx235054-100ug 100 ug
EUR 481

MDM1-Specific Antibody

abx235076-100ug 100 ug
EUR 509

MEF2C-Specific Antibody

abx235107-100ug 100 ug
EUR 481

MYH10-Specific Antibody

abx235472-100ug 100 ug
EUR 481

MYH4-Specific Antibody

abx235476-100ug 100 ug
EUR 509

MYH7-specific Antibody

abx235478-100ug 100 ug
EUR 509

MYOM1-Specific Antibody

abx235516-100ug 100 ug
EUR 481

MYPN-Specific Antibody

abx235525-100ug 100 ug
EUR 551

MYSM1-Specific Antibody

abx235527-100ug 100 ug
EUR 551

NARFL-Specific Antibody

abx235553-100ug 100 ug
EUR 509

NEB-Specific Antibody

abx235638-100ug 100 ug
EUR 509

Neogenin-Specific Antibody

abx235662-100ug 100 ug
EUR 481

neurturin-Specific Antibody

abx235683-100ug 100 ug
EUR 551

NFIX-Specific Antibody

abx235701-100ug 100 ug
EUR 509

Embryo development outcomes include fertilisation, blastocyst formation and quality, and embryo cryopreservation and utilisation. The study was reviewed and approved by the Ethics Review Boards of the participating centres. Eligible women will sign a written informed consent before enrolment.

This study has an independent data monitoring and safety committee comprised international experts in trial design and in vitro culture. No plan exists to disseminate results to participants or health communities, except for the independent monitoring and safety committee of the trial.