One potential stressor that can affect preimplantation and postimplantation embryonic growth after in vitro fertilisation (IVF) is the pH of the human embryo culture medium, but no evidence exists to indicate which pH level is optimal for IVF.
Based on anecdotal evidence or mouse models, culture media manufacturers recommend a pH range of 7.2 to 7.4, and IVF laboratories routinely use a pH range of 7.25 to 7.3. Given the lack of randomised trials evaluating the effect of pH on live birth rate after IVF, this trial examines the effect of three different pH levels on the live birth rate.
This multicentre randomised trial will involve centres specialised in IVF in Egypt. Eligible couples for intracytoplasmic sperm injection (ICSI) will be randomised for embryo culture at pH 7.2, 7.3 or 7.4. The study is designed to detect 10 percentage points difference in live birth rate between the best and worst performing media with 93% power at a 1% significance level.
The primary outcome is the rate of live birth (delivery of one or more viable infants beyond the 20th week of gestation) after ICSI. Secondary clinical outcomes include biochemical pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, preterm births, birth weight, stillbirth, congenital malformation and cumulative live birth (within 1 year from randomisation).
Allele-In-One Human Blood Direct PCR Kit |
ABP-PP-BD02100 |
Allele Biotech |
100 RXNS |
Ask for price |
|
Allele-In-One Human Blood Direct PCR Kit |
ABP-PP-BD02500 |
Allele Biotech |
500 RXNS |
Ask for price |
|
Allele-In-One Mouse Tail Direct Lysis Buffer |
ABP-PP-MT01100 |
Allele Biotech |
100 RXNS |
Ask for price |
|
Allele-In-One Mouse Tail Direct Lysis Buffer |
ABP-PP-MT01500 |
Allele Biotech |
500 RXNS |
Ask for price |
|
Allele-In-One Mouse Tail Direct PCR Kit |
ABP-PP-MT02100 |
Allele Biotech |
100 RXNS |
Ask for price |
|
Allele-In-One Mouse Tail Direct PCR Kit |
ABP-PP-MT02500 |
Allele Biotech |
500 RXNS |
Ask for price |
|
Human nonmethylated oligonucleotide(NON)ELISA Kit |
GA-E1908HM-48T |
GenAsia Biotech |
48T |
EUR 289 |
Human nonmethylated oligonucleotide(NON)ELISA Kit |
GA-E1908HM-96T |
GenAsia Biotech |
96T |
EUR 466 |
Human nonmethylated oligonucleotide,NON ELISA Kit |
201-12-1892 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Oligonucleotide Binding Fold Containing 1 Protein |
20-abx262451 |
Abbexa |
-
EUR 328.00
-
EUR 6397.00
-
EUR 230.00
|
|
|
Human nonmethylated oligonucleotide,NON ELISA Kit |
CN-04463H1 |
ChemNorm |
96T |
EUR 452 |
Human nonmethylated oligonucleotide,NON ELISA Kit |
CN-04463H2 |
ChemNorm |
48T |
EUR 302 |
ELISA kit for Human Nonmethylated oligonucleotide (NON) |
KTE62600-48T |
Abbkine |
48T |
EUR 354 |
|
Description: Quantitative sandwich ELISA for measuring Human Nonmethylated oligonucleotide (NON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Nonmethylated oligonucleotide (NON) |
KTE62600-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2252 |
|
Description: Quantitative sandwich ELISA for measuring Human Nonmethylated oligonucleotide (NON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Nonmethylated oligonucleotide (NON) |
KTE62600-96T |
Abbkine |
96T |
EUR 572 |
|
Description: Quantitative sandwich ELISA for measuring Human Nonmethylated oligonucleotide (NON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Testis-specific kinase substrate (TSKS) polyclonal antibody |
ABP-PAB-10265 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease (SENP1) polyclonal antibody |
ABP-PAB-11087 |
Allele Biotech |
100 ug |
Ask for price |
|
Ubiquitin specific protease 6 (USP6) polyclonal antibody |
ABP-PAB-11313 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 1 (SENP1) polyclonal antibody |
ABP-PAB-10330 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 1 (SENP1) polyclonal antibody |
ABP-PAB-10331 |
Allele Biotech |
100 ug |
Ask for price |
|
SUMO1/sentrin specific protease 6 (SENP6) polyclonal antibody |
ABP-PAB-10338 |
Allele Biotech |
100 ug |
Ask for price |
|
SUMO1/sentrin specific protease 6 (SENP6) polyclonal antibody |
ABP-PAB-10339 |
Allele Biotech |
100 ug |
Ask for price |
|
Brain-specific angiogenesis inhibitor 1 (BAI1) polyclonal antibody |
ABP-PAB-10421 |
Allele Biotech |
100 ug |
Ask for price |
|
Brain-specific angiogenesis inhibitor 2 (BAI2) polyclonal antibody |
ABP-PAB-10422 |
Allele Biotech |
100 ug |
Ask for price |
|
Brain-specific angiogenesis inhibitor 3 (BAI3) polyclonal antibody |
ABP-PAB-10423 |
Allele Biotech |
100 ug |
Ask for price |
|
Kallikrein 3 (KLK3, Prostate Specific Antigen, PSA) polyclonal antibody |
ABP-PAB-10235 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 5 (SENP5, MGC27076) polyclonal antibody |
ABP-PAB-10336 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 5 (SENP5, MGC27076) polyclonal antibody |
ABP-PAB-10337 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 2, N-terminus (SENP2) polyclonal antibody |
ABP-PAB-10332 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 2, C-terminus (SENP2) polyclonal antibody |
ABP-PAB-10333 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 3, N-terminus (SENP3) polyclonal antibody |
ABP-PAB-10334 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 3, C-terminus (SENP3) polyclonal antibody |
ABP-PAB-10335 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 7, N-terminus (SENP7) polyclonal antibody |
ABP-PAB-10340 |
Allele Biotech |
100 ug |
Ask for price |
|
Sentrin/SUMO-specific protease 7, C-terminus (SENP7) polyclonal antibody |
ABP-PAB-10341 |
Allele Biotech |
100 ug |
Ask for price |
|
OBFC1 Oligonucleotide Binding Fold Containing 1 Human Recombinant Protein |
PROTQ9H668 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: OBFC1 Human Recombinant produced in E. coli is. a single polypeptide chain containing 391 amino acids (1-368) and having a molecular mass of 44.5kDa. OBFC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Human Suppressor of G2 allele of SKP1 homolog, SUGT1 ELISA KIT |
ELI-52628h |
Lifescience Market |
96 Tests |
EUR 824 |
Bovine Suppressor of G2 allele of SKP1 homolog, SUGT1 ELISA KIT |
ELI-13668b |
Lifescience Market |
96 Tests |
EUR 928 |
Mouse Suppressor of G2 allele of SKP1 homolog, Sugt1 ELISA KIT |
ELI-18768m |
Lifescience Market |
96 Tests |
EUR 865 |
Mouse Ig gamma- 2A chain C region, A allele, Ighg ELISA KIT |
ELI-47186m |
Lifescience Market |
96 Tests |
EUR 865 |
REDD1 Specific (REDD1 specific) Antibody |
abx237228-100ug |
Abbexa |
100 ug |
EUR 509 |
|
TDRKH Specific (TDRKH specific) Antibody |
abx238580-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Human TDRKH specific (TDRKH specific) ELISA Kit |
abx259882-96tests |
Abbexa |
96 tests |
EUR 911 |
|
ACADL-Specific Antibody |
abx230064-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ADAM17-Specific Antibody |
abx230139-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ADRA1A-Specific Antibody |
abx230177-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ADRA2B-Specific Antibody |
abx230179-100ug |
Abbexa |
100 ug |
EUR 509 |
|
AFF1-Specific Antibody |
abx230195-100ug |
Abbexa |
100 ug |
EUR 481 |
|
AKAP11-Specific Antibody |
abx230251-100ug |
Abbexa |
100 ug |
EUR 481 |
|
AMPD1-Specific Antibody |
abx230370-100ug |
Abbexa |
100 ug |
EUR 509 |
|
ARF5-Specific Antibody |
abx230534-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ARF6-Specific Antibody |
abx230535-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ARHGEF9-Specific Antibody |
abx230565-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ARSK-Specific Antibody |
abx230613-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ATF2-Specific Antibody |
abx230661-100ug |
Abbexa |
100 ug |
EUR 481 |
|
ATP1A1-Specific Antibody |
abx230692-100ug |
Abbexa |
100 ug |
EUR 509 |
|
ATP1A2-Specific Antibody |
abx230694-100ug |
Abbexa |
100 ug |
EUR 509 |
|
ATP5G2-Specific Antibody |
abx230708-100ug |
Abbexa |
100 ug |
EUR 481 |
|
BAG1S-specific Antibody |
abx230788-100ug |
Abbexa |
100 ug |
EUR 509 |
|
BAI2-Specific Antibody |
abx230791-100ug |
Abbexa |
100 ug |
EUR 481 |
|
BAI3-Specific Antibody |
abx230792-100ug |
Abbexa |
100 ug |
EUR 481 |
|
Barkor-Specific Antibody |
abx230806-100ug |
Abbexa |
100 ug |
EUR 481 |
|
BRN2-Specific Antibody |
abx230963-100ug |
Abbexa |
100 ug |
EUR 481 |
|
BTF3L3-Specific Antibody |
abx230976-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CAPG-Specific Antibody |
abx231249-100ug |
Abbexa |
100 ug |
EUR 481 |
|
Catalase-Specific Antibody |
abx231302-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CCKAR-specific Antibody |
abx231377-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CCKBR-specific Antibody |
abx231378-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CCR2-specific Antibody |
abx231390-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CCT6A-Specific Antibody |
abx231401-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CD68-Specific Antibody |
abx231493-100ug |
Abbexa |
100 ug |
EUR 509 |
|
CDH10-specific Antibody |
abx231546-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CDK1-Specific Antibody |
abx231552-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CEACAM3-Specific Antibody |
abx231578-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CEP350-Specific Antibody |
abx231603-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CES7-Specific Antibody |
abx231618-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CHST13-Specific Antibody |
abx231693-100ug |
Abbexa |
100 ug |
EUR 509 |
|
CISD2-Specific Antibody |
abx231719-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CPNE9-Specific Antibody |
abx231932-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CPT1B-specific Antibody |
abx231944-100ug |
Abbexa |
100 ug |
EUR 509 |
|
CPT1C-specific Antibody |
abx231946-100ug |
Abbexa |
100 ug |
EUR 481 |
|
CRLS1-Specific Antibody |
abx231983-100ug |
Abbexa |
100 ug |
EUR 509 |
|
CST2-Specific Antibody |
abx232033-100ug |
Abbexa |
100 ug |
EUR 481 |
|
MCL1L-specific Antibody |
abx235054-100ug |
Abbexa |
100 ug |
EUR 481 |
|
MDM1-Specific Antibody |
abx235076-100ug |
Abbexa |
100 ug |
EUR 509 |
|
MEF2C-Specific Antibody |
abx235107-100ug |
Abbexa |
100 ug |
EUR 481 |
|
MYH10-Specific Antibody |
abx235472-100ug |
Abbexa |
100 ug |
EUR 481 |
|
MYH4-Specific Antibody |
abx235476-100ug |
Abbexa |
100 ug |
EUR 509 |
|
MYH7-specific Antibody |
abx235478-100ug |
Abbexa |
100 ug |
EUR 509 |
|
MYOM1-Specific Antibody |
abx235516-100ug |
Abbexa |
100 ug |
EUR 481 |
|
MYPN-Specific Antibody |
abx235525-100ug |
Abbexa |
100 ug |
EUR 551 |
|
MYSM1-Specific Antibody |
abx235527-100ug |
Abbexa |
100 ug |
EUR 551 |
|
NARFL-Specific Antibody |
abx235553-100ug |
Abbexa |
100 ug |
EUR 509 |
|
NEB-Specific Antibody |
abx235638-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Neogenin-Specific Antibody |
abx235662-100ug |
Abbexa |
100 ug |
EUR 481 |
|
neurturin-Specific Antibody |
abx235683-100ug |
Abbexa |
100 ug |
EUR 551 |
|
NFIX-Specific Antibody |
abx235701-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Embryo development outcomes include fertilisation, blastocyst formation and quality, and embryo cryopreservation and utilisation. The study was reviewed and approved by the Ethics Review Boards of the participating centres. Eligible women will sign a written informed consent before enrolment.
This study has an independent data monitoring and safety committee comprised international experts in trial design and in vitro culture. No plan exists to disseminate results to participants or health communities, except for the independent monitoring and safety committee of the trial.